GO Terms |
Score |
Description |
GO:0003674 |
90.20% |
molecular_function |
GO:0005488 |
90.12% |
binding |
GO:0003676 |
88.93% |
nucleic acid binding |
GO:1901363 |
88.48% |
heterocyclic compound binding |
GO:0097159 |
88.45% |
organic cyclic compound binding |
GO:0003677 |
87.65% |
DNA binding |
GO:0140110 |
82.40% |
transcription regulator activity |
GO:0043565 |
82.10% |
sequence-specific DNA binding |
GO:0003700 |
81.13% |
DNA-binding transcription factor activity |
GO:0003690 |
79.90% |
double-stranded DNA binding |
GO:0000981 |
78.75% |
DNA-binding transcription factor activity, RNA polymerase II-specific |
GO:1990837 |
78.54% |
sequence-specific double-stranded DNA binding |
GO:0000976 |
75.76% |
transcription regulatory region sequence-specific DNA binding |
GO:0001067 |
75.44% |
regulatory region nucleic acid binding |
GO:0000977 |
75.31% |
RNA polymerase II regulatory region sequence-specific DNA binding |
GO:0044212 |
75.22% |
transcription regulatory region DNA binding |
GO:0001012 |
75.06% |
RNA polymerase II regulatory region DNA binding |
GO:0000987 |
68.81% |
proximal promoter sequence-specific DNA binding |
GO:0000978 |
68.74% |
RNA polymerase II proximal promoter sequence-specific DNA binding |
GO:0001227 |
33.02% |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO:0001217 |
32.88% |
DNA-binding transcription repressor activity |
GO:0005515 |
19.87% |
protein binding |
GO:0001228 |
19.86% |
DNA-binding transcription activator activity, RNA polymerase II-specific |
GO:0001216 |
19.58% |
DNA-binding transcription activator activity |
GO:0046872 |
12.93% |
metal ion binding |
GO:0043169 |
12.90% |
cation binding |
GO:0003682 |
12.82% |
chromatin binding |
GO:0043167 |
11.65% |
ion binding |
GO:0008134 |
11.41% |
transcription factor binding |
GO:0019904 |
11.27% |
protein domain specific binding |
GO:0140297 |
10.62% |
DNA-binding transcription factor binding |
GO:0046983 |
9.96% |
protein dimerization activity |
GO:0042802 |
9.52% |
identical protein binding |
GO:0046914 |
9.07% |
transition metal ion binding |
GO:0008270 |
8.91% |
zinc ion binding |
GO:0019899 |
8.32% |
enzyme binding |
GO:0061629 |
8.29% |
RNA polymerase II-specific DNA-binding transcription factor binding |
GO:0042826 |
7.92% |
histone deacetylase binding |
GO:0046982 |
7.35% |
protein heterodimerization activity |
GO:0044877 |
6.84% |
protein-containing complex binding |
GO:0001221 |
6.68% |
transcription cofactor binding |
GO:0003712 |
6.33% |
transcription coregulator activity |
GO:0035035 |
6.33% |
histone acetyltransferase binding |
GO:0070888 |
6.21% |
E-box binding |
GO:0003723 |
6.09% |
RNA binding |
GO:0001223 |
5.76% |
transcription coactivator binding |
GO:0042803 |
5.75% |
protein homodimerization activity |
GO:0001047 |
5.74% |
core promoter binding |
GO:0003714 |
5.53% |
transcription corepressor activity |
GO:0001046 |
5.51% |
core promoter sequence-specific DNA binding |
GO:0019900 |
5.25% |
kinase binding |
GO:0008022 |
5.01% |
protein C-terminus binding |
GO:1990841 |
5.01% |
promoter-specific chromatin binding |
GO:0003713 |
4.92% |
transcription coactivator activity |
GO:0031490 |
4.84% |
chromatin DNA binding |
GO:0046332 |
4.76% |
SMAD binding |
GO:0036094 |
4.74% |
small molecule binding |
GO:0001222 |
4.69% |
transcription corepressor binding |
GO:1901265 |
4.63% |
nucleoside phosphate binding |
GO:0019901 |
4.62% |
protein kinase binding |
GO:0008327 |
4.57% |
methyl-CpG binding |
GO:0003730 |
4.53% |
mRNA 3'-UTR binding |
GO:0000166 |
4.46% |
nucleotide binding |
GO:0001099 |
4.43% |
basal RNA polymerase II transcription machinery binding |
GO:0044389 |
4.40% |
ubiquitin-like protein ligase binding |
GO:0008013 |
4.33% |
beta-catenin binding |
GO:0061980 |
4.24% |
regulatory RNA binding |
GO:0008301 |
4.24% |
DNA binding, bending |
GO:0005102 |
4.22% |
signaling receptor binding |
GO:0030331 |
4.16% |
estrogen receptor binding |
GO:0098772 |
4.13% |
molecular function regulator |
GO:0001098 |
4.12% |
basal transcription machinery binding |
GO:0031625 |
4.11% |
ubiquitin protein ligase binding |
GO:0016922 |
4.10% |
nuclear receptor binding |
GO:0001091 |
4.08% |
RNA polymerase II general transcription initiation factor binding |
GO:0140296 |
4.08% |
general transcription initiation factor binding |
GO:0030234 |
4.05% |
enzyme regulator activity |
GO:0035257 |
4.01% |
nuclear hormone receptor binding |
GO:0008092 |
3.99% |
cytoskeletal protein binding |
GO:0002039 |
3.89% |
p53 binding |
GO:0008047 |
3.88% |
enzyme activator activity |
GO:0042393 |
3.84% |
histone binding |
GO:0003697 |
3.74% |
single-stranded DNA binding |
GO:0003729 |
3.70% |
mRNA binding |
GO:0051427 |
3.69% |
hormone receptor binding |
GO:0035258 |
3.67% |
steroid hormone receptor binding |
GO:0015631 |
3.63% |
tubulin binding |
GO:0043621 |
3.61% |
protein self-association |
GO:0003684 |
3.39% |
damaged DNA binding |
GO:0051018 |
3.37% |
protein kinase A binding |
GO:0031072 |
3.29% |
heat shock protein binding |
GO:0051721 |
3.14% |
protein phosphatase 2A binding |
GO:0035198 |
3.12% |
miRNA binding |
GO:0047485 |
3.08% |
protein N-terminus binding |
GO:0043168 |
2.98% |
anion binding |
GO:0004879 |
2.92% |
nuclear receptor activity |
GO:0043425 |
2.90% |
bHLH transcription factor binding |
GO:0090079 |
2.85% |
translation regulator activity, nucleic acid binding |
GO:0005507 |
2.83% |
copper ion binding |
GO:0098531 |
2.81% |
ligand-activated transcription factor activity |
GO:0019902 |
2.81% |
phosphatase binding |
GO:0019903 |
2.80% |
protein phosphatase binding |
GO:0051019 |
2.76% |
mitogen-activated protein kinase binding |
GO:0003824 |
2.76% |
catalytic activity |
GO:0017091 |
2.74% |
AU-rich element binding |
GO:0035925 |
2.74% |
mRNA 3'-UTR AU-rich region binding |
GO:0097367 |
2.69% |
carbohydrate derivative binding |
GO:0003727 |
2.69% |
single-stranded RNA binding |
GO:0005516 |
2.67% |
calmodulin binding |
GO:0070063 |
2.65% |
RNA polymerase binding |
GO:0051020 |
2.61% |
GTPase binding |
GO:0036002 |
2.59% |
pre-mRNA binding |
GO:0017025 |
2.59% |
TBP-class protein binding |
GO:0030374 |
2.59% |
nuclear receptor transcription coactivator activity |
GO:0008144 |
2.59% |
drug binding |
GO:0043021 |
2.57% |
ribonucleoprotein complex binding |
GO:0016740 |
2.57% |
transferase activity |
GO:0003779 |
2.56% |
actin binding |
GO:0035639 |
2.55% |
purine ribonucleoside triphosphate binding |
GO:0005524 |
2.55% |
ATP binding |
GO:0060589 |
2.52% |
nucleoside-triphosphatase regulator activity |
GO:0140097 |
2.48% |
catalytic activity, acting on DNA |
GO:0016818 |
2.46% |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
GO:0004407 |
2.45% |
histone deacetylase activity |
GO:0051879 |
2.44% |
Hsp90 protein binding |
GO:0042974 |
2.43% |
retinoic acid receptor binding |
GO:0030695 |
2.43% |
GTPase regulator activity |
GO:0019209 |
2.42% |
kinase activator activity |
GO:0016817 |
2.42% |
hydrolase activity, acting on acid anhydrides |
GO:0016462 |
2.40% |
pyrophosphatase activity |
GO:0030554 |
2.40% |
adenyl nucleotide binding |
GO:0060089 |
2.39% |
molecular transducer activity |
GO:0030295 |
2.37% |
protein kinase activator activity |
GO:0032559 |
2.37% |
adenyl ribonucleotide binding |
GO:0032553 |
2.35% |
ribonucleotide binding |
GO:0019207 |
2.34% |
kinase regulator activity |
GO:0032555 |
2.32% |
purine ribonucleotide binding |
GO:0019787 |
2.31% |
ubiquitin-like protein transferase activity |
GO:0042162 |
2.27% |
telomeric DNA binding |
GO:0005096 |
2.26% |
GTPase activator activity |
GO:0017076 |
2.26% |
purine nucleotide binding |
GO:0016787 |
2.23% |
hydrolase activity |
GO:0017136 |
2.23% |
NAD-dependent histone deacetylase activity |
GO:0003785 |
2.19% |
actin monomer binding |
GO:0034979 |
2.18% |
NAD-dependent protein deacetylase activity |
GO:0017111 |
2.18% |
nucleoside-triphosphatase activity |
GO:0008017 |
2.17% |
microtubule binding |
GO:0140030 |
2.16% |
modification-dependent protein binding |
GO:0061659 |
2.16% |
ubiquitin-like protein ligase activity |
GO:0003725 |
2.16% |
double-stranded RNA binding |
GO:0140096 |
2.12% |
catalytic activity, acting on a protein |
GO:0033558 |
2.10% |
protein deacetylase activity |
GO:0060090 |
2.08% |
molecular adaptor activity |
GO:0019887 |
2.05% |
protein kinase regulator activity |
GO:0048037 |
2.04% |
cofactor binding |
GO:0045182 |
2.03% |
translation regulator activity |
GO:0031420 |
2.02% |
alkali metal ion binding |
GO:0071889 |
2.02% |
14-3-3 protein binding |
GO:0008289 |
2.01% |
lipid binding |
GO:0003688 |
1.98% |
DNA replication origin binding |
GO:0002020 |
1.98% |
protease binding |
GO:0019789 |
1.95% |
SUMO transferase activity |
GO:0030674 |
1.95% |
protein binding, bridging |
GO:0030371 |
1.95% |
translation repressor activity |
GO:0016251 |
1.94% |
RNA polymerase II general transcription initiation factor activity |
GO:0016746 |
1.94% |
transferase activity, transferring acyl groups |
GO:0016887 |
1.92% |
ATPase activity |
GO:0140223 |
1.92% |
general transcription initiation factor activity |
GO:0031369 |
1.91% |
translation initiation factor binding |
GO:0033218 |
1.90% |
amide binding |
GO:0050699 |
1.90% |
WW domain binding |
GO:0019213 |
1.90% |
deacetylase activity |
GO:0019208 |
1.87% |
phosphatase regulator activity |
GO:0051087 |
1.87% |
chaperone binding |
GO:0051059 |
1.83% |
NF-kappaB binding |
GO:0016747 |
1.81% |
transferase activity, transferring acyl groups other than amino-acyl groups |
GO:0031491 |
1.80% |
nucleosome binding |
GO:0051015 |
1.80% |
actin filament binding |
GO:0042277 |
1.79% |
peptide binding |
GO:0016811 |
1.77% |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
GO:0051219 |
1.76% |
phosphoprotein binding |
GO:0008168 |
1.72% |
methyltransferase activity |
GO:0042623 |
1.72% |
ATPase activity, coupled |
GO:0005509 |
1.72% |
calcium ion binding |
GO:0016407 |
1.72% |
acetyltransferase activity |
GO:0043175 |
1.71% |
RNA polymerase core enzyme binding |
GO:0038023 |
1.71% |
signaling receptor activity |
GO:0016410 |
1.71% |
N-acyltransferase activity |
GO:0008080 |
1.69% |
N-acetyltransferase activity |
GO:0016810 |
1.69% |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
GO:0004674 |
1.68% |
protein serine/threonine kinase activity |
GO:0030332 |
1.68% |
cyclin binding |
GO:0004857 |
1.66% |
enzyme inhibitor activity |
GO:0005496 |
1.64% |
steroid binding |
GO:0004672 |
1.62% |
protein kinase activity |
GO:0008276 |
1.62% |
protein methyltransferase activity |
GO:0016504 |
1.61% |
peptidase activator activity |
GO:0016741 |
1.60% |
transferase activity, transferring one-carbon groups |
GO:0030544 |
1.59% |
Hsp70 protein binding |
GO:0017124 |
1.59% |
SH3 domain binding |
GO:0005080 |
1.59% |
protein kinase C binding |
GO:0016301 |
1.58% |
kinase activity |
GO:0051117 |
1.58% |
ATPase binding |
GO:0032182 |
1.57% |
ubiquitin-like protein binding |
GO:0050681 |
1.56% |
androgen receptor binding |
GO:0000217 |
1.56% |
DNA secondary structure binding |
GO:0004402 |
1.54% |
histone acetyltransferase activity |
GO:0000993 |
1.53% |
RNA polymerase II complex binding |
GO:1901681 |
1.52% |
sulfur compound binding |
GO:0008170 |
1.50% |
N-methyltransferase activity |
GO:0042054 |
1.49% |
histone methyltransferase activity |
GO:0004842 |
1.48% |
ubiquitin-protein transferase activity |
GO:0008157 |
1.47% |
protein phosphatase 1 binding |
GO:0017069 |
1.46% |
snRNA binding |
GO:0035064 |
1.46% |
methylated histone binding |
GO:0042805 |
1.46% |
actinin binding |
GO:0098847 |
1.46% |
sequence-specific single stranded DNA binding |
GO:0020037 |
1.45% |
heme binding |
GO:0061733 |
1.44% |
peptide-lysine-N-acetyltransferase activity |
GO:0061630 |
1.43% |
ubiquitin protein ligase activity |
GO:0005543 |
1.43% |
phospholipid binding |
GO:0043022 |
1.42% |
ribosome binding |
GO:0044390 |
1.41% |
ubiquitin-like protein conjugating enzyme binding |
GO:0034237 |
1.41% |
protein kinase A regulatory subunit binding |
GO:0016773 |
1.41% |
phosphotransferase activity, alcohol group as acceptor |
GO:0046966 |
1.41% |
thyroid hormone receptor binding |
GO:0005198 |
1.41% |
structural molecule activity |
GO:0008757 |
1.41% |
S-adenosylmethionine-dependent methyltransferase activity |
GO:0140034 |
1.41% |
methylation-dependent protein binding |
GO:0045296 |
1.40% |
cadherin binding |
GO:0005215 |
1.39% |
transporter activity |
GO:0070840 |
1.39% |
dynein complex binding |
GO:0046906 |
1.38% |
tetrapyrrole binding |
GO:0034212 |
1.38% |
peptide N-acetyltransferase activity |
GO:0030545 |
1.37% |
receptor regulator activity |
GO:0051536 |
1.37% |
iron-sulfur cluster binding |
GO:0031267 |
1.36% |
small GTPase binding |
GO:0097718 |
1.33% |
disordered domain specific binding |
GO:0051540 |
1.33% |
metal cluster binding |
GO:0030546 |
1.33% |
signaling receptor activator activity |
GO:0043178 |
1.32% |
alcohol binding |
GO:0016772 |
1.32% |
transferase activity, transferring phosphorus-containing groups |
GO:0030165 |
1.31% |
PDZ domain binding |
GO:1990381 |
1.29% |
ubiquitin-specific protease binding |
GO:0043130 |
1.28% |
ubiquitin binding |
GO:0008187 |
1.28% |
poly-pyrimidine tract binding |
GO:0048487 |
1.25% |
beta-tubulin binding |
GO:0050839 |
1.24% |
cell adhesion molecule binding |
GO:0031624 |
1.23% |
ubiquitin conjugating enzyme binding |
GO:0003707 |
1.23% |
steroid hormone receptor activity |
GO:0016279 |
1.21% |
protein-lysine N-methyltransferase activity |
GO:0016278 |
1.21% |
lysine N-methyltransferase activity |
GO:0016788 |
1.20% |
hydrolase activity, acting on ester bonds |
GO:0016491 |
1.20% |
oxidoreductase activity |
GO:0018024 |
1.20% |
histone-lysine N-methyltransferase activity |
GO:0005126 |
1.19% |
cytokine receptor binding |
GO:0043028 |
1.19% |
cysteine-type endopeptidase regulator activity involved in apoptotic process |
GO:0032934 |
1.18% |
sterol binding |
GO:0061134 |
1.18% |
peptidase regulator activity |
GO:0005539 |
1.18% |
glycosaminoglycan binding |
GO:0019838 |
1.17% |
growth factor binding |
GO:0008135 |
1.16% |
translation factor activity, RNA binding |
GO:0004888 |
1.15% |
transmembrane signaling receptor activity |
GO:0003823 |
1.14% |
antigen binding |
GO:0043015 |
1.14% |
gamma-tubulin binding |
GO:0017022 |
1.14% |
myosin binding |
GO:0019955 |
1.14% |
cytokine binding |
GO:0005085 |
1.13% |
guanyl-nucleotide exchange factor activity |
GO:0004386 |
1.12% |
helicase activity |
GO:0070851 |
1.11% |
growth factor receptor binding |
GO:0070034 |
1.08% |
telomerase RNA binding |
GO:0048306 |
1.08% |
calcium-dependent protein binding |
GO:0004713 |
1.08% |
protein tyrosine kinase activity |
GO:0060590 |
1.07% |
ATPase regulator activity |
GO:0032452 |
1.06% |
histone demethylase activity |
GO:0016538 |
1.06% |
cyclin-dependent protein serine/threonine kinase regulator activity |
GO:0015485 |
1.06% |
cholesterol binding |
GO:0042578 |
1.05% |
phosphoric ester hydrolase activity |
GO:0022857 |
1.05% |
transmembrane transporter activity |
GO:0070300 |
1.04% |
phosphatidic acid binding |
GO:0019888 |
1.04% |
protein phosphatase regulator activity |
GO:0043539 |
1.03% |
protein serine/threonine kinase activator activity |
GO:0004518 |
1.02% |
nuclease activity |
GO:0032451 |
1.01% |
demethylase activity |
GO:0005048 |
1.01% |
signal sequence binding |
GO:0050897 |
1.01% |
cobalt ion binding |